Material Safety Data Sheet

Diethyl Pyrocarbonate

ACC# 91383
Section 1 - Chemical Product and Company Identification

*MSDS Name:* Diethyl Pyrocarbonate
*Catalog Numbers:* BP251525, BP25155, BP251550, BP25155100 *
Synonyms:* DEPC; Diethyl Oxydiformate; Diethyl Dicarbonate; Ethyl
Pyrocarbonate. *
Company Identification:*
              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410 *
For information, call:* 201-796-7100 *
Emergency Number:* 201-796-7100 *
For CHEMTREC assistance, call:* 800-424-9300 *
For International CHEMTREC assistance, call:* 703-527-3887

Section 2 - Composition, Information on Ingredients


*CAS#* 	*Chemical Name* 	*Percent* 	*EINECS/ELINCS*
1609-47-8	Diethyl pyrocarbonate 	ca 100 	216-542-8


Section 3 - Hazards Identification


*EMERGENCY OVERVIEW*

Appearance: clear, colorless liquid. Flash Point: 157 deg F.
* Warning!* Causes respiratory tract irritation. Irritant. Causes eye
and skin irritation. May be absorbed through intact skin.* Combustible
liquid and vapor.* May be harmful if swallowed. May cause digestive
tract irritation. May cause central nervous system depression. Moisture
sensitive.
*Target Organs: *Central nervous system.


*Potential Health Effects*
*Eye:* Causes eye irritation. May cause chemical conjunctivitis and
corneal damage.
*Skin:* Causes skin irritation. May be absorbed through the skin in
harmful amounts. May cause irritation and dermatitis. May cause cyanosis
of the extremities.
*Ingestion:* May cause gastrointestinal irritation with nausea, vomiting
and diarrhea. May be harmful if swallowed.
*Inhalation:* Causes respiratory tract irritation. Aspiration may lead
to pulmonary edema. Can produce delayed pulmonary edema. Inhalation at
high concentrations may cause CNS depression and asphixiation.
*Chronic:* Effects may be delayed.

Section 4 - First Aid Measures



*Eyes:* Immediately flush eyes with plenty of water for at least 15
minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
*Skin:* Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
*Ingestion:* Never give anything by mouth to an unconscious person. Get
medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth
and drink 2-4 cupfuls of milk or water.
*Inhalation:* Remove from exposure and move to fresh air immediately. If
not breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
*Notes to Physician:* Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures



*General Information:* As in any fire, wear a self-contained breathing
apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and
full protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion. Use water spray
to keep fire-exposed containers cool. Combustible liquid. Vapors may be
heavier than air. They can spread along the ground and collect in low or
confined areas. Containers may explode when heated.
*Extinguishing Media:* Use water spray to cool fire-exposed containers.
Do NOT get water inside containers. Use water spray, dry chemical,
carbon dioxide, or appropriate foam.
*Flash Point:* 157e deg F ( 69.44 deg C)
*Autoignition Temperature:* Not applicable.
*Explosion Limits, Lower:*Not available.
* Upper:* Not available.
*NFPA Rating:* (estimated) Health: 2; Flammability: 2; Instability: 0

Section 6 - Accidental Release Measures



*General Information:* Use proper personal protective equipment as
indicated in Section 8.
*Spills/Leaks:* Absorb spill with inert material (e.g. vermiculite, sand
or earth), then place in suitable container. Clean up spills
immediately, observing precautions in the Protective Equipment section.
Scoop up with a nonsparking tool, then place into a suitable container
for disposal. Remove all sources of ignition. Provide ventilation. Do
not get water inside containers.

Section 7 - Handling and Storage



*Handling:* Wash hands before eating. Remove contaminated clothing and
wash before reuse. Use only in a well-ventilated area. Avoid contact
with eyes, skin, and clothing. Empty containers retain product residue,
(liquid and/or vapor), and can be dangerous. Keep container tightly
closed. Keep away from heat, sparks and flame. Avoid ingestion and
inhalation. Do not allow contact with water. Wash clothing before reuse.
Do not pressurize, cut, weld, braze, solder, drill, grind, or expose
empty containers to heat, sparks or open flames. Keep from contact with
moist air and steam.
*Storage:* Keep away from heat, sparks, and flame. Keep away from
sources of ignition. Store in a tightly closed container. Store in a
cool, dry, well-ventilated area away from incompatible substances. Keep
refrigerated. (Store below 4°C/39°F.) Store protected from moisture.

Section 8 - Exposure Controls, Personal Protection



*Engineering Controls:* Facilities storing or utilizing this material
should be equipped with an eyewash facility and a safety shower. Use
adequate ventilation to keep airborne concentrations low.
*Exposure Limits*
*Chemical Name* 	*ACGIH* 	*NIOSH* 	*OSHA - Final PELs*
Diethyl pyrocarbonate	none listed 	none listed 	none listed


*OSHA Vacated PELs:* Diethyl pyrocarbonate: No OSHA Vacated PELs are
listed for this chemical.
*Personal Protective Equipment*
*Eyes:* Wear appropriate protective eyeglasses or chemical safety
goggles as described by OSHA's eye and face protection regulations in 29
CFR 1910.133 or European Standard EN166.
*Skin:* Wear appropriate protective gloves to prevent skin exposure.
*Clothing:* Wear appropriate protective clothing to prevent skin exposure.
*Respirators:* A respiratory protection program that meets OSHA's 29 CFR
1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be
followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties



*Physical State:* Liquid
*Appearance:* clear, colorless
*Odor:* Fruity odor.
*pH:* Not available.
*Vapor Pressure:* Not available.
*Vapor Density:* Not available.
*Evaporation Rate:*Not available.
*Viscosity:* Not available.
*Boiling Point:* 60 deg C @ 3 mmHg
*Freezing/Melting Point:*Not available.
*Decomposition Temperature:*Not available.
*Solubility:* Decomposed by water.
*Specific Gravity/Density:*1.1
*Molecular Formula:*C6H10O5
*Molecular Weight:*162.067

Section 10 - Stability and Reactivity



*Chemical Stability:* Stable at room temperature in closed containers
under normal storage and handling conditions.
*Conditions to Avoid:* High temperatures, mechanical shock, incompatible
materials, ignition sources, moisture, excess heat, exposure to moist
air or water.
*Incompatibilities with Other Materials:* Moisture, ammonia, strong
acids, strong bases, strong oxidizing agents, strong reducing agents.
*Hazardous Decomposition Products:* Carbon monoxide, irritating and
toxic fumes and gases, carbon dioxide.
*Hazardous Polymerization:* Has not been reported.

Section 11 - Toxicological Information



*RTECS#:*      
*CAS#* 1609-47-8: LQ9350000
*LD50/LC50:*
CAS# 1609-47-8:
     Oral, mouse: LD50 = 1558 mg/kg;
     Oral, rabbit: LD50 = 500 mg/kg;
     Oral, rat: LD50 = 850 mg/kg;

*Carcinogenicity:*
CAS# 1609-47-8: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

*Epidemiology:* No information found.
*Teratogenicity:* No information found.
*Reproductive Effects:* No information found.
*Mutagenicity:* No information found.
*Neurotoxicity:* No information found.
*Other Studies:*

Section 12 - Ecological Information


No information available.

Section 13 - Disposal Considerations


Chemical waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the
classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous
waste regulations to ensure complete and accurate classification.
*RCRA P-Series:* None listed.
*RCRA U-Series:* None listed.

Section 14 - Transport Information


* * 	*US DOT* 	*Canada TDG*
*Shipping Name:* 	Not regulated as a hazardous material 	No information
available.
*Hazard Class:* 		
*UN Number:* 		
*Packing Group:* 		


Section 15 - Regulatory Information


*US FEDERAL**
*
*TSCA*
     CAS# 1609-47-8 is listed on the TSCA inventory.
*Health & Safety Reporting List*
     None of the chemicals are on the Health & Safety Reporting List.
*Chemical Test Rules*
     None of the chemicals in this product are under a Chemical Test Rule.
*Section 12b*
     None of the chemicals are listed under TSCA Section 12b.
*TSCA Significant New Use Rule*
     None of the chemicals in this material have a SNUR under TSCA.
*CERCLA Hazardous Substances and corresponding RQs*
     None of the chemicals in this material have an RQ.
*SARA Section 302 Extremely Hazardous Substances*
     None of the chemicals in this product have a TPQ.
*SARA Codes*
     CAS # 1609-47-8: acute, flammable, reactive.
*Section 313*      No chemicals are reportable under Section 313.
*Clean Air Act:*
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
*Clean Water Act:*
     None of the chemicals in this product are listed as Hazardous
Substances under the CWA.
     None of the chemicals in this product are listed as Priority
Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic
Pollutants under the CWA.
*OSHA:*
     None of the chemicals in this product are considered highly
hazardous by OSHA.
*STATE*
     CAS# 1609-47-8 is not present on state lists from CA, PA, MN, MA,
FL, or NJ.

*California Prop 65*

California No Significant Risk Level: None of the chemicals in this
product are listed. *

European/International Regulations*
*European Labeling in Accordance with EC Directives*
*Hazard Symbols:*
     XN *
Risk Phrases:*
     R 20/21/22 Harmful by inhalation, in contact with skin and if
     swallowed.
     R 36/37/38 Irritating to eyes, respiratory system and skin.
*
Safety Phrases:*
*
WGK (Water Danger/Protection)*
     CAS# 1609-47-8: No information available.
*Canada - DSL/NDSL*
     CAS# 1609-47-8 is listed on Canada's DSL List.
*Canada - WHMIS*
     This product has a WHMIS classification of B3, D2B.
*Canadian Ingredient Disclosure List*

Section 16 - Additional Information


*MSDS Creation Date:* 2/01/2000
*Revision #3 Date:* 3/18/2003
/
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect
to such information, and we assume no liability resulting from its use.
Users should make their own investigations to determine the suitability
of the information for their particular purposes. In no event shall
Fisher be liable for any claims, losses, or damages of any third party
or for lost profits or any special, indirect, incidental, consequential
or exemplary damages, howsoever arising, even if Fisher has been advised
of the possibility of such damages. /