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J. Neurophysiol. 67: 332-340 (1992)
Mathematical model of an identified stomatogastric
ganglion neuron.
Buchholtz F, Golowasch J, Epstein IR, Marder E
Department of Chemistry, Brandeis University,
Waltham, Massachusetts 02254-9110.
- The ionic currents in the lateral pyloric (LP) cell of the stomatogastric
ganglion (STG) described in the preceding paper of the rock crab Cancer
borealis were fit with a set of differential equations that describe their
voltage, time, and Ca2+ dependence. The voltage-dependent currents
modeled are a delayed rectifier-like current, id; a Ca2+-activated
outward current, io(Ca); a transient A-like current, iA;
a Ca2+ current, iCa; an inwardly rectifying current,
ih; and a fast tetrodotoxin (TTX)-sensitive Na+ current,
iNa.
- A single-compartment, isopotential model of the LP cell was constructed
from the six voltage-dependent currents, a voltage-independent leak current
il, a Ca2+ buffering system, and the membrane capacitance.
- The behavior of the model LP neuron was compared with that of the biological
neuron by simulating physiological experiments carried out in both voltage-clamp
and current-clamp modes. The model and biological neurons show similar
action-potential shapes, durations, steady-state current-voltage (I-V)
curves, and respond to injected current in a comparable way.
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