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J. Neurophysiol. 67: 318-331 (1992)
Ionic currents of the lateral pyloric neuron of
the stomatogastric ganglion of the crab.
Golowasch J, Marder E
Department of Biology, Brandeis University, Waltham,
Massachusetts 02254-9110.
- The lateral pyloric (LP) neuron is an important component of the network
that generates the pyloric rhythm of the stomatogastric ganglion (STG)
and is a direct target of many modulatory inputs to the STG. Our aim in
this and the subsequent two papers is to describe the conductances present
in this cell and to understand the role these conductances play in shaping
the activity of the neuron.
- LP neurons were studied in two-electrode voltage clamp (TEVC) in a
saline solution containing tetrodotoxin (TTX) and picrotoxin (PTX) to isolate
them pharmacologically from presynaptic inputs.
- We identified six voltage-dependent ionic conductances. These include
three outward currents that resemble a delayed rectifier current, a Ca2+-activated
K+ current and an A-current similar to those seen in many other
preparations. LP neurons show three inward currents, a fast TTX-sensitive
current, a hyperpolarization-activated inward current, and a Ca2+
current.
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